歡迎光臨~杭州紐羅西敏生物科技有限公司
  咨詢電話:0571-88254427

行業新聞及文獻

SARS-CoV-2 and other coronaviruses bind to phosphorylated glycans from the human lung

SARS-CoV, MERS-CoV, and potentially SARS-CoV-2 emerged as novel human coronaviruses following cross-species transmission from animal hosts. Although the receptor binding characteristics of human coronaviruses are well documented, the role of carbohydrate binding in addition to recognition of proteinaceous receptors has not been fully explored. Using natural glycan microarray technology, we identified N-glycans in the human lung that are recognized by various human and animal coronaviruses. All viruses tested, including SARS-CoV-2, bound strongly to a range of phosphorylated, high mannose N-glycans and to a very specific set of sialylated structures. Examination of two linked strains, human CoV OC43 and bovine CoV Mebus, reveals shared binding to the sialic acid form Neu5Gc (not found in humans), supporting the evidence for cross-species transmission of the bovine strain. Our findings, revealing robust recognition of lung glycans, suggest that these receptors could play a role in the initial stages of coronavirus attachment and entry

聯系我們

聯系人:

手 機:0571-88254427

郵 箱:info@neuro-hemin.com

公 司:杭州紐羅西敏生物科技有限公司

地 址:杭州市教工路316號

jealousvue日本成熟50maof